I've had Fedora on my desktop at work for a few months now, and now I'm thinking about dumping Windows at home too.
Except for a few apps like Quicken, and maybe a few games, I think I should be able to make the switch to Fedora at home pretty seamless. I might be able to get around that by using Wine, or maybe even doing the virtual machine thing. I will probably lose the cool function keys on my new keyboard though, unless I can find a way to make them work in Fedora.
Before I make the switch, I'll need to do some research and see if anybody out there has posted any experience with some of my more commonly used apps under Linux.