Imablog Perspectives of a Canadian in the Old/Deep/New/Geographic South: This is where I ramble on about nothing in particular and post a few nice pictures.

Posts from March 2008

A new blog/wiki project

A few weeks ago while I was updating some of the dog park pages over at Charleston Wiki, the thought crossed my mind that I should do a Charleston Dog Park Tour. I'd take the dogs to each of the dog parks in the area, take a bunch of pictures of the park and the dogs playing there and write about them. Good blog/wiki fodder I figured and it seemed like it would be a fun thing to do.

I'd have a little more to put down for the respective wiki entries and the pictures would make a nice supplement.

Maybe I could even take it on the road and do a Lowcountry Dog Park tour.

I know the dogs certainly wouldn't mind, especially if there were ponds to check out and test for swim-ability.

Who wants to come along?

Dark...again

I just wanted to offer my thanks to the US government for their immense wisdom in pushing DST back three weeks and making me wake up in the dark again. The extra two weeks of morning darkness I'll be getting is just what I needed.

Thanks again.

Photography meetup

Just a reminder that Wednesday is the second meetup for the 21st Century Photography (Digital & Film) Meetup Group. The first meetup was a nice social gathering where we all got to learn a little bit about everybody.

Let's explore the latest high tech trends, new smaller and smaller cameras, swap tips and techniques, share images, experiences and expectations -- and have fun doing it!

This next meetup is going to be a bit of a show-and-tell with people bringing in selections of some of their photos to show off. I'll have my laptop and projector to throw everbody's photos up onto the wall (I guess I better check the projector and make sure it still works). I might even remember to bring my laser pointer too.

If you're already part of the group, bring some of your photos along on CD or thumb/flash drive.

If you're not, check out the group and sign up if you're interested. We'd love to have you.

Possible adopter for Hannah

Yay! Got word today that someone was interested in Hannah! They will be coming by on Thursday to meet Hannah and if all goes well she'll have a new forever home.

I must admit I'm a little sad at the prospect of her leaving, but if that means she'll be going to a nice home where she'll get spoiled and loved on like she does here, then that makes me happy.

Hannah's mugshot

Arsenic PET imaging

When most people think of PET imaging, the more commonly used isotopes of 18F, 11C, 15O and 82Rb usually come to mind. When this article on arsenic imaging (free registration required I think) showed up in my feed reader a few days ago, I was a little intrigued. It certainly wouldn't be the first time a toxic metal was used for imaging purposes. 201Tl has been used as a cardiac imaging agent for years and is still used in a lot of places. Fortunately, the amounts used are way below toxicity levels making it safe to use for imaging.

The article looks at some research being done using 74As tagged to bavituximab (an antibody). So being curious, I looked up the decay scheme for 74As. It produces a β+ 66% of the time and a β- 34% of the time with mean beta energies of 440 and 400 keV respectively. That means it should have good spatial resolution characteristics (travels a shorter distance from the decay point before annihilating). The half life of 17.77 days makes it less than ideal as an imaging agent though, but perfect for research because it allows researchers to follow the imaging characteristics of anything tagged to 74As without having to do repeated injections.

From the article:

A study published in the latest issue of the journal Clinical Cancer Research (14 1377) shows that arsenic behaves as a promising functional imaging agent when linked to a developmental anti-cancer drug called bavituximab, an antibody that homes in on the blood vessels that feed cancerous tumours. The findings, which are based on animal studies, mark the first time that arsenic has been used to label antibodies for the detection of tumours.

Significantly, there appears to be little or no detectable uptake of bavituximab by normal organs, with 22 times as much bavituximab localized to the tumour compared to the liver when measured 72 hours post-injection. The study further showed no specific localization of bavituximab to blood or other tissues, including the heart, kidney, intestine, muscle, bone and brain.

It's all still in the research phase but it sounds interesting. It will probably be a few years before anything is ready for clinical research on people but it sounds like there's a lot of potential.

Abstract from the paper:

Purpose: We recently reported that anionic phospholipids, principally phosphatidylserine, become exposed on the external surface of vascular endothelial cells in tumors, probably in response to oxidative stresses present in the tumor microenvironment. In the present study, we tested the hypothesis that a chimeric monoclonal antibody that binds phosphatidylserine could be labeled with radioactive arsenic isotopes and used for molecular imaging of solid tumors in rats.

Experimental Design: Bavituximab was labeled with 74As (β+, T1/2 17.8 days) or 77As (β-, T1/2 1.6 days) using a novel procedure. The radionuclides of arsenic were selected because their long half-lives are consistent with the long biological half lives of antibodies in vivo and because their chemistry permits stable attachment to antibodies. The radiolabeled antibodies were tested for the ability to image subcutaneous Dunning prostate R3227-AT1 tumors in rats.

Results: Clear images of the tumors were obtained using planar {gamma}-scintigraphy and positron emission tomography. Biodistribution studies confirmed the specific localization of bavituximab to the tumors. The tumor-to-liver ratio 72 h after injection was 22 for bavituximab compared with 1.5 for an isotype-matched control chimeric antibody of irrelevant specificity. Immunohistochemical studies showed that the bavituximab was labeling the tumor vascular endothelium.

Conclusions: These results show that radioarsenic-labeled bavituximab has potential as a new tool for imaging the vasculature of solid tumors.

A lotta yotta storage

A research group estimates that the amount of digital data created and stored will reach nearly 2 zettabytes by 2011. That's 2x1021 bytes.

That's a lot of crap to store.

Well, not all of it is crap, but I'm sure a good chunk of it is crap.

From the article:

By 2011, there will be 1,800 exabytes of electronic data in existence, or 1.8 zettabytes (an exabyte is equal to 1 billion gigabytes). In fact, the number of bits stored already exceeds the estimated number of stars in the universe, IDC stated. And because data is growing by a factor of 10 every five years, by 2023 the number of stored bits will surpass Avogadro's number, which is the number of carbon atoms in 12 grams, or 602,200,000,000,000,000,000,000 (6.022 x 10^23).

Less than half of the digital data being created by individuals can be accounted for by user activities, such as photos, phone calls and e-mails. The majority of the data is made up by what IDC calls digital "shadows" &emdash; including surveillance photos, Web search histories, financial transaction journals and mailing lists.

At roughly 14 terabytes/year (and growing), I know that our department is making it's contribution to the 'storage economy'.

Methinks we'll need some new prefixes soon for whatever comes after 1024

Found via Slashdot.

I need this

Yesterday one of the dog owners showed up at the dog park with one of these.

It's from a company called Hyper Products. They make a few other neat things that I'd link to, but their entire site is Flash-based so there's nothing to link to (hate it when people do that).

This would be perfect for playing with out at JICP.

St. Labby Day

Psst, hey dogs.

If you're out and about this weekend and looking for a fun event to pull drag bring your people to, come to the St. Labby Day party Wild Heir Labrador Rescue is putting on! There's going to be lots of fun things going on, lots of dogs to check out and play with and all kinds of games to play. Don't worry, there will be stuff for your people to do too so they don't feel left out.

Maybe you'll even convince your people to get you that brother or sister you always wanted!

Come on out! It'll be fun! The party's on Saturday, March 15 over at The Square Onion in I'On Square, 18B Resolute Lane, Mount Pleasant. Come early so you don't miss the good treats!

A new family

Well, that didn't take long at all.

The woman and her friend came by and pretty much fell in love with Hannah right away. Hannah hit it off with them too. I gave them a run down of the training I've done with her, her behaviour quirks and personality traits. Now she's off to be with her new family. I think she'll be in a great home and get plenty of love and spoiling. They were really nice people and fairly young, so I think she'll be with them a long long while.

Feels good to know she's got a good home to go to now (not that she didn't have one here of course).

Posted
14 March 2008 @ 2PM

Tagged
Uncategorized

No Comments Yet

On fostering

This was posted by someone over in a lab forum that I hang out in

I am the bridge between what was and what can be.
I am the pathway to a new life.
I am made of mush, because my heart melted when I saw you
Matted and sore, limping, depressed, lonely, unwanted, afraid to love.
For one little time you are mine. I will feed you with my own hand
I will love you with my whole heart, I will make you whole.
I am made of steel
Because when the time comes,
When you are well and sleek,
When your eyes shine,
And your tail wags with joy-
Then comes the hard part.
I will let you go-- not without a tear, But without a regret.
For you are safe forever. A new dog needs me now.
By Diane Morgan

St. Labby Day fun

Yesterday's St. Labby Day party for WHLR turned out to be a little more than what I expected. I drove out there expecting to see just a small meet and greet type type thing set up, but it ended up being a whole block party instead.

Turned out to be somewhat chaotic but very fun. Both litters of puppies were out there and were hugely popular with the kids (as usual). The fundraising raffle was a pretty big success and we gave out a bunch of application forms. I think we also finalized 4 o 6 adoptions yesterday too which was great. Don't think we sold quite as much stuff as we did during SEWE, but we generate a lot of interest.

Pictures from the event are here

Desk decluttered

After moving the computer setup to the other desk, I was thoroughly disgusted by the rats nest of cabling building up. Although not as bad as some I've seen, it was getting pretty messy around the desk.

So, inspired by Declutter Your Desk, I decided to DIY a solution based on the peg board method.

A few before shots:


I decided to do the side and back of the desk using pegboard. On the side I used the lock shackle and peg method shown on Declutter Your Desk since this side was going to be supporting the most weight with all the gadgets. This was all done pretty much as described, except with the shackles oriented vertically.

On the back since I was only planning on securing cables, I went with eye screws and S hooks. This let the pegboard swing free and is easy to move around. Just drill a few pilot holes into the desk and screw in the eye screws.

After that was done came the task of arranging and attaching everything to the pegboard. I used zipties instead of wire.

And here's how everything looks after:

The UPS is far too heavy to mount on the pegboard, so it stays on the floor.

Shopping list (I already had a bunch of zip ties, so didn't need to buy those.):
2 2'x4'x1/8" pegboard - $3.53 each
3 2.5" lock clasps - $2.56 each
Open S hooks (package of 6) - $0.88
1 1/8" eye screws (package of 10) - $0.90
5/16"x48" dowel - $0.68
Total cost: $17.20

Hannah update

It's been almost a week since Hannah was adopted out, and today I got another update from her new mom. It was in the form of a mother's letter to daughter explaining the process they went through to get Hannah. Sounds like Hannah and the daughter are already best of friends and getting along marvelously and that Hannah's in just the right home she needs to be in.

Hannah was a great dog to have around and I miss having her here, but getting the letter and knowing she's in a great new home where she'll get way more attention than I could give her makes it all worthwhile.

Vacation coming up so it'll be a few more weeks before I think I'll get another dog to foster. Can't wait to see what the next one will be like.

More work on the horizon

I have a feeling this is going to mean that I'm going to be a lot busier in the near future.

UnitedHealthcare (UHc) will require all facilities performing diagnostic imaging to obtain appropriate accreditation by third quarter 2008, in order to continue receiving reimbursements for many imaging procedures. The deadline had previously been March 1.
UHc has recognized the ACR and the Intersocietal Accreditation Commission as acceptable accrediting organizations for medical imaging, and has designated the following modalities as falling under the mandate: CT, CT angiography, MRI, MR angiography, PET, nuclear medicine/cardiology and echocardiography.

Two down, too soon

A few days ago I learned that my friend's dad passed away after having a stroke. Although I only met him a couple of times, I seem to remember him being pretty cool for a dad.

Yesterday I learned one of the volunteers I work with at the Aquarium passed away over the weekend from a heart attack. He always gave me the latest updates with the birds when I came in for my Saturday morning shift. It will be strange not seeing him around and hearing his stories.

Sad days all around.

Dog foster homes needed

Do you have room to foster a dog? If so, then Wild Heir Labrador Rescue could really use a hand.

Wild Heir Labrador Rescue needs you......

If you are not familiar with Wild Heir Labrador rescue, it is an organization that saves unwanted Labrador retrievers. We work to save labs from all over South Carolina ,as well as ,throughout Georgia and North Carolina. We acquire our labs from kill shelters throughout the area, owner surrenders and good Samaritans. At the present time we have about 40 adult labs and 19 puppies in our rescue. One thing that makes us unique is that all of our labs are in foster homes- we do not have a kennel facility and believe that our labs become better adjusted being in a family home environment. Which brings me to the purpose of this email- we are DESPERATELY looking for foster homes immediately.....

We have just gotten notice on approximately 13 labs that need to be removed from shelters in Greenville, Florence and Walterboro- their time is up and they will be euthanized unless someone comes to get them. Wild Heir always rises to the occasion and we do what we have to do to save every lab that we can- however- we need somewhere for them to go once we have picked them up. We are asking for any foster homes that may be available- please consider fostering a lab and please forward this email to anyone and everyone you know. It doesn't matter where you live- if you are willing to foster we will bring the lab to you.

Fostering can be an amazing experience- it is a short term way to open your heart and your home to a lab in need. We provide transport and all vetting. You provide love and food. Even if you can only commit to a short period of time, or you think your home may not be the best suited for a lab- any loving foster home is better than the shelter or death. If you are interested in becoming a foster parent to one of these great labs or you have any questions please contact me as soon as possible. Thank you-

Journal Club: From Baking a Cake to Solving the Schrödinger Equation

This latest installment of the journal club isn't exactly medical physics related, but it was something that I thought was interesting more from a topical point of view rather than the actual research itself.

The title of the paper, From Baking a Cake to Solving the Schrödinger Equation, may give the impression of being just another trivial waste of time and a candidate for an Ig Nobel award.

Look a little deeper and it actually turns out to be much more.

Physics is all about developing, describing and modeling systems or processes, which is exactly what this paper is about. Once you have a decent model, you use it to make predictions and design experiments to verify those predictions. The author takes a seemingly trivial process (how changes in cake dimension and volume affect baking time) and attempts to describe the process mathematically using well known equations and experimental results.

Found via Talk Like A Physicist

First comes the initial model. The authors begin with the diffusion equation.

Along with some known initial conditions, the equation can be solved to produce a solution that approximates the cake baking process. In the case of the paper, the solution provides the baking time given the dimensions of the cake.

Once the solutions have been obtained, it's now possible to visualize the theoretical behaviour of the system. However, this still needs to be correlated to the actual observed behaviour, which is where the experimental part comes in. If the experimental results deviate from the expected theoretical results, it probably means that some of the assumptions in the model were incorrect and need to be modified. Usually it's possible to figure out how the model needs to be modified by studying the differences between the theoretical and experimental results. With the modified model, a new set of solutions can be created and then verified against experimental results.

With enough iterations, the model becomes accurate enough to make predictions that can be verified experimentally. Often new experiments need to be designed in order to verify any predictions made. Sometimes current technology is insufficient and verifying predictions must wait years or decades before it can be done. If you're really clever, you notice that the solutions of the model can be applied to other systems, or you notice that the solution or equations resemble a process in a completely unrelated field. In the paper, the author notes the similarity between the diffusion equation and Shrödinger's equation and analyzes not only what the solutions mean when applied to the Shrödinger equation, but also the limitations of the solutions.

Thus, rather than being an apparently trivial paper, this paper is really a very impressive study of what physics and the process of doing physics is all about.

Abstract:

The primary emphasis of this study has been to explain how modifying a cake recipe by changing either the dimensions of the cake or the amount of cake batter alters the baking time. Restricting our consideration to the génoise, one of the basic cakes of classic French cuisine, we have obtained a semi-empirical formula for its baking time as a function of oven temperature, initial temperature of the cake batter, and dimensions of the unbaked cake. The formula, which is based on the Diffusion equation, has three adjustable parameters whose values are estimated from data obtained by baking génoises in cylindrical pans of various diameters. The resulting formula for the baking time exhibits the scaling behavior typical of diffusion processes, i.e. the baking time is proportional to the (characteristic length scale) of the cake. It also takes account of evaporation of moisture at the top surface of the cake, which appears to be a dominant factor affecting the baking time of a cake. In solving this problem we have obtained solutions of the Diffusion equation which are interpreted naturally and straightforwardly in the context of heat transfer; however, when interpreted in the context of the Schrödinger equation, they are somewhat peculiar. The solutions describe a system whose mass assumes different values in two different regions of space. Furthermore, the solutions exhibit characteristics similar to the evanescent modes associated with light waves propagating in a wave guide. When we consider the Schrödinger equation as a non-relativistic limit of the Klein-Gordon equation so that it includes a mass term, these are no longer solutions.